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This study examines human papillomavirus (HPV) infection and reactivation among older women (born between 1945 and 1964) and the persistence and progression of this infection to cervical cancer. Specifically, investigators propose to assemble a prospective cohort of 1500 racially and socioeconomically diverse women for HPV infection and squamous intraepithelial lesions (SIL). The objectives of this study are to: (1) compare the prevalence, incidence and duration of HPV infection and SIL by menopausal status (pre-, peri-, and postmenopausal); and (2) estimate the minimum levels for detecting HPV DNA and seroconversion associated with reactivation as compared with a new sexual exposures to the virus. Investigators expect this study to provide stable estimates of the likelihood of detecting a new HPV infection or SIL as the result of menopausal changes and new sexual exposures compared to reactivation of the virus.
For more information contact NCI Program Director: Vaurice Starks
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