National Cancer Institute
Behavioral Research - Cancer Control and Population Sciences

Key Initiatives

Epidemiology Studies Regarding HPV and Cervical Cancer

Natural History of HPV Infection in Men: The HIM Study

Investigator: Anna R. Giuliano

In the United States, Hispanic women have significantly higher rates of cervical cancer than non-Hispanic White women. Human papillomavirus (HPV), a sexually transmitted infection, is the central cause of invasive cervical and other anogenital cancers, including anal, penile, vaginal and vulvar cancers. Little is known, however, about the prevalence, incidence, and clearance of HPV infection in men. The HPV in Men (HIM) Study will prospectively study men in the United States and Mexico to determine the incidence and persistence of penile HPV infections; immune response to HPV; and factors associated with the acquisition, persistence, and clearance of type-specific HPV infections in men.

HIM Study specific aims are to: (1) establish a cohort of 3,000 men ages 18 - 44 years; (2) determine the incidence and persistence of type specific penile HPV infection (investigating 38 different types that infect the genital tract) among men residing in Mexico (high-risk) and the United States (low-risk); (3) investigate the humoral immune response to HPV infection; and (4) identify multiple risk factors independently associated with acquisition, persistence, and clearance of type-specific HPV infections in men. Ultimately, the findings may provide information useful in designing vaccine efficacy studies in men and may eventually lead to a reduction in the cancer burden in both men and women.

For more information contact NCI Program Director: Vaurice Starks

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Last Updated: January 5, 2012

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