National Cancer Institute
Behavioral Research - Cancer Control and Population Sciences

Key Initiatives

Epidemiology Studies Regarding HPV and Cervical Cancer

Pregnancy After LEEP

Investigator: George A. Macones

The Loop Electrosurgical Excision Procedure (LEEP) is used commonly in the United States to treat cervical dysplasia. This study will examine the association between LEEP and preterm birth < 34 weeks.

Because there is an association between cervix length and preterm birth, LEEP may increase the risk of preterm birth and other adverse pregnancy outcomes. This retrospective cohort study will be the largest observational study to investigate the link between LEEP and preterm birth < 34 weeks. Women from nine hospitals in the Delaware Valley will be studied in three groups: (1) "exposed" women who have undergone LEEP, (2) "nonexposed" women who have had a cervical punch biopsy without LEEP, and (3) "nonexposed" women who have undergone neither LEEP nor cervical punch biopsy. The study endpoint will be the occurrence of a spontaneous preterm birth < 34 weeks. Secondary endpoints will include preterm birth at < 37 and < 28 weeks, spontaneous miscarriage, midtrimester pregnancy loss, and length of gestation. The study also will explore whether the depth and width of the LEEP are associated with preterm birth < 34 weeks.

For more information contact NCI Program Director: Vaurice Starks

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Last Updated: January 5, 2012

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