Ellen R. Gritz, Ph.D., Co-Chair Professor and Chair Department of Behavioral Science M.D. Anderson Cancer Center Houston, TX Caryn Lerman, Ph.D., Co-Chair Professor of Medicine and Psychiatry Director, Cancer Genetics Georgetown University Medical Center Washington, DC     David Abrams, Ph.D. Professor & Director Behavioral Medicine Brown University School of Medicine/The Miriam Hospital Providence, RI Nancy Breen, Ph.D. Economist Applied Research Branch Division of Cancer Control and Population Sciences National Cancer Institute Bethesda, MD Neil Caporaso, M.D. Chief Pharmacogenetics Section Genetic Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda, MD Virginia L. Ernster, Ph.D. Professor and Vice Chair Department of Epidemiology and Biostatistics University of California, San Francisco Ellen Feigal, M.D. Deputy Director Division of Cancer Treatment and Diagnosis National Cancer Institute Bethesda, MD Thomas J. Glynn, Ph.D. Director Cancer Science and Trends American Cancer Society Atlanta, GA Bruce E. Johnson, M.D. Head Lung Cancer Biology Section Medicine Branch at the Navy National Naval Medical Center Bethesda, MD Lin Li, Ph.D., M.P.H. Fellow Tobacco Control Research Branch Division of Cancer Control and Population Sciences National Cancer Institute Bethesda, MD David Longfellow, Ph.D. Chief Chemical & Physical Carcinogenesis Branch Division of Cancer Biology National Cancer Institute Bethesda, MD Marc Manley, M.D., M.P.H. Chief Tobacco Control Research Branch Division of Cancer Control and Population Sciences National Cancer Institute Bethesda, MD Sherry Mills, M.D., M.P.H. Chief Applied Sociocultural Research Branch Division of Cancer Control and Population Sciences National Cancer Institute Bethesda, MD John D. Minna, M.D. Director Hamon Center for Therapeutic Oncology Research University of Texas Southwestern Medical Center Dallas, TX C. Tracy Orleans, Ph.D. Senior Research and Program Officer The Robert Wood Johnson Foundation Princeton, NJ Joe Patel, Ph.D. Program Director Epidemiology and Genetics Program Division of Cancer Control and Population Sciences National Cancer Institute Bethesda, MD Barbara K. Rimer, Dr.P.H. Director Division of Cancer Control and Population Sciences National Cancer Institute Bethesda, MD Harold Seifried, Ph.D. Program Director Division of Cancer Biology National Cancer Institute Bethesda, MD Peter Shields, M.D. Chief Molecular Epidemiology Section Laboratory of Human Carcinogenesis Division of Basic Sciences National Cancer Institute Bethesda, MD Don Shopland Coordinator Smoking and Tobacco Control Program Division of Cancer Control and Population Sciences National Cancer Institute Bethesda, MD Susan Solomon, Ph.D. Senior Advisor Office of Behavioral and Social Sciences Research National Institutes of Health Bethesda, MD Frances Stillman, Ed.D. Public Health Advisor Behavioral Research Program Division of Cancer Control and Population Sciences National Cancer Institute Bethesda, MD Jaylan Turkkan, Ph.D. Chief Behavioral Sciences Research Branch Division of Basic Research National Institute on Drug Abuse Rockville, MD Ex-officio Members: Robert Wittes, M.D. Director Division of Cancer Treatment Director of Extramural Sciences National Cancer Institute Bethesda, MD Robert A. Hiatt, M.D., Ph.D. Deputy Director Division of Cancer Control and Population Sciences National Cancer Institute Bethesda, MD Expert Testimony: Gregory Connolly, D.M.D., M.P.H. Director Massachusetts Tobacco Control Program Massachusetts Department of Public Health Boston, MA Richard R. Clayton, Ph.D. Representative Society for Research on Nicotine and Tobacco Rockville, MD Stanton A. Glanz, Ph.D. Division of Cardiology University of California San Francisco, CA Facilitator: Marianne H. Alciati, Ph.D. Management Solutions for Health Reston, VA Support Contractor: MasiMax Resources, Inc. R.O.W. Sciences, Inc. (subcontractor) Rockville, MD Acknowledgements: Thanks are due to staff members of the Division of Cancer Control and Population Sciences for their contributions to this report. Joan Becker facilitated communication among members, including the establishment of a listserv, and helped gather and verify information for the portfolio analysis. Stacey Vandor obtained intramural information for the portfolio analysis. Glen Morgan, Ph.D., played a vital role in all stages of the final execution of this report. Finally, the NCI Board of Scientific Advisors provided extremely helpful comments that were used to refine this report.