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National Cancer Institute

Monograph 20: Phenotypes and Endophenotypes Foundations for Genetic Studies of Nicotine Use and Dependence

Monograph 20 cover

This monograph reviews the scientific foundation for genetic studies of nicotine use and dependence. The authors and editors—representing a wide range of expertise in the fields of psychology, psychiatry, behavioral pharmacology, neurobiology, epidemiology, statistical genetics, and bioinformatics—reviewed and analyzed the growing body of research findings in the field to develop a scientific plan for incorporating genetic research into crossdisciplinary studies of nicotine dependence. This monograph provides important, innovative, and new concepts and methodologies for behavioral genetics. This information can help direct future research, tailor treatment decisions for individual smokers, and guide public health policy in tobacco prevention and control.

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