Monograph 20: Phenotypes and Endophenotypes Foundations for Genetic Studies of Nicotine Use and Dependence

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Monograph 20 cover

Monograph 20: Phenotypes and Endophenotypes
Foundations for Genetic Studies of Nicotine Use and Dependence

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Entire Monograph (PDF 13,232 KB)
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Table of Contents:

Part 1 – Introduction

  • Chapter 1
    Overview and Conclusions
    (PDF 110 KB)
    • Introduction
    • About the Monograph
    • Major Accomplishments
    • Major Conclusions
    • Chapter Summaries and Conclusions
    • References

  • Chapter 2
    Status of Genetic Studies of Nicotine Dependence

    (363 KB)
    • Introduction
    • Historical Perspective of Genetic Research on Nicotine Dependence
    • Nicotine Dependence: A Construct in Need of Refinement
    • Nicotine-Dependence Phenotypes: A Framework
    • Gentic Epidemiological Concepts and Their Implications for Studying Nicotine Dependence
    • Summary of Selected Biometric and Measured Genetic Studies of Nicotine Dependence
    • Issues in Communication of Genetic Findings
    • Summary
    • References

Part 2 – Theoretical Considerations

Part 3 – Developmental Trajectories of Tobacco Use and Their Relation to Tobacco Dependence (PDF)

  • Chapter 5
    Developmental Trajectories of Cigarette Smoking from Adolescence to Adulthood
    (PDF 285 KB)
    • Introduction
    • A Developmental Psychopathology Perspective: Studying Multiple Trajectories over Time
    • Empirically Identified Trajectories of Adolescent Smoking
    • Statistical Models for Evaluating Alternative Developmental Phenotypes of Smoking Behavior
    • An Empirical Example: Trajectories in the Indiana University Smoking Survey
    • Future Research Directions
    • Summary
    • Conclusions
    • References

  • Chapter 6
    Genetic Modeling of Tobacco Use Behavior and Trajectories
    (PDF 484 KB)
    • Introduction
    • Methodological and Conceptual Issues
    • Statistical Framework
    • Review of Genetic Studies of Smoking
    • Item Response Theory Approach: Application to Virginia Twin Registry Data
    • Limitations
    • Summary
    • Conclusions
    • References

  • Chapter 7
    Trajectories of Tobacco Use from Adolescence to Adulthood: Are the Most Informative Phenotypes Tobacco Specific?
    • Introduction
    • Importance of Studying Substance-Use Comorbidity
    • Common Versus Specific Liability to Substance-Use Disorders
    • Review of Trajectory Literature
    • Associations between Substance-Use Trajectories and Other Substance Involvement
    • Modeling Conjoint Trajectories of Substance Use
    • Empirical Example of Modeling Co-Occurring Courses of Substance Use
    • Method
    • Results
    • Summary
    • Conclusions
    • References

Part 4 – Endophenotypes

  • Chapter 8
    Endophenotypes for Nicotine-Dependence Risk at or before Initial Nicotine Exposure
    (PDF 352 KB)
    • Introduction
    • Endophenotypes
    • Smoking Initiation and Progression Risk: Examination of Key Candidate Psychological Domains
    • Initial Nicotine Exposure Response: Conceptual Framework and Candidate Endophenotypes
    • Discussion of Future Directions
    • Summary
    • Conclusions
    • References

  • Chapter 9
    Nicotine-Dependence Endophenotypes in Chronic Smokers
    (PDF 389 KB)
    • Introduction
    • Rationale for Investigating Endophenotypes of Chronic Nicotine Exposure
    • Motivational Mechanisms
    • Acute Smoking or Abstinence Effects on Cognitive, Affective, and Physiological Function
    • Discussion and Recommendations for Future Research
    • Summary
    • Conclusions
    • References

Part 5 – Epidemiological and Methodological Considerations (PDF)

Part 6 – Future Directions

  • Chapter 13
    Future Directions
    (PDF 122 KB)
    • Introduction
    • Genetics and Nicotine Dependence: Implications for Basic and Clinical Research
    • Future Directions
    • References

Index (PDF 116 KB)