NCI/DCCPS Funding Opportunity Announcements for Clinical Trials

For due dates on or after January 25, 2018, NIH will require that all applications involving one or more clinical trials be submitted through a Funding Opportunity Announcement (FOA) specifically designed for clinical trials. Note that NIH supports all types of clinical trials (mechanistic, exploratory/developmental, pilot/feasibility, pragmatic, behavioral, and others), so be sure to see this page to determine if any of the human subjects research within your proposal meets the definition of a clinical trial.

The FOAs listed within this page allow clinical trials that are relevant for the scientific areas supported by NCI DCCPS. (See https://grants.nih.gov/policy/clinical-trials/specific-funding-opportunities.htm for more information on clinical trial-specific funding opportunities.). Reissued FOAs include language indicating whether clinical trials are required, meaning the proposed research must include at least one NIH-defined clinical trial, whether they are optional, meaning the proposed research may include at least one NIH-defined clinical trial, or whether they are not allowed, meaning the proposed research may not include any NIH-defined clinical trial. Please read carefully the specific language when selecting the appropriate FOA.

NCI Omnibus Announcements

Title Announcement Expiration Date Clinical Trial Optional / Required?
Academic Research Enhancement Award PA-18-343 (R15 Clinical Trial Required) January 8, 2021 Required
NCI Small Grants Program for Cancer Research PAR-18-021 (NCI Omnibus R03 Clinical Trial Optional) January 8, 2020 Optional
National Cancer Institute Program Project Applications PAR-18-290 (P01 Clinical Trial Optional) January 8, 2020 Optional

Behavioral Research

Title Announcement Expiration Date Contact Clinical Trial Optional / Required?
Physical Activity and Weight Control Interventions Among Cancer Survivors: Effects on Biomarkers of Prognosis and Survival PAR-18-893 (R01 Clinical Trial Optional)
PAR-18-892 (R21 Clinical Trial Optional)
September 8, 2021 Frank Perna
240-276-6782
pernafm@mail.nih.gov
Optional
Exploratory/Developmental Clinical Research Grants in Obesity PA-18-720 (R21 Clinical Trial Optional) May 8, 2021 Tanya Agurs-Collins
240-276-6956
collinsta@mail.nih.gov
Optional
End-of-Life and Palliative Care Health Literacy: Improving Outcomes in Serious, Advanced Illness PA-18-498 (R01 Clinical Trial Optional)
PA-18-499 (R21 Clinical Trial Optional)
May 8, 2021 Sylvia Chou
240-276-6954
chouws@mail.nih.gov
Optional
Cancer Prevention and Control Clinical Trials Grant Program PAR-18-559 (R01 Clinical Trial Required) January 8, 2021 Susan Czajkowski
240-276-5871
czajkows@nci.nih.gov
Required
Testing Interventions for Health-Enhancing Physical Activity PAR-17-306 (R01 Clinical Trial Optional)
PAR-18-307 (R21/R33 Clinical Trial Optional)
January 8, 2021 Frank Perna
240-276-6782
pernafm@mail.nih.gov
Optional
Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services PAR-18-222 (R01 Clinical Trial Optional) November 14, 2020 Glen Morgan
240-276-6787
gmorgan@nih.gov
Optional
U.S. Tobacco Control Policies to Reduce Health Disparities PAR-18-675 (R01 Clinical Trial Optional)
PAR-18-674 (R21 Clinical Trial Optional)
June 16, 2020 Bob Vollinger
240-276-6919
Bob.Vollinger@nih.gov

Annette Kaufman
240-276-6706
kaufmana@mail.nih.gov
Optional
Stimulating Innovations in Behavioral Intervention Research for Cancer Prevention and Control PAR-18-018 (R21 Clinical Trial Optional) May 8, 2020 Tanya Agurs-Collins
240-276-6956
collinsta@mail.nih.gov
Optional
Oral Anticancer Agents: Utilization, Adherence, and Health Care Delivery PA-18-004 (R01 Clinical Trial Optional)
PA-18-014 (R21 Clinical Trial Optional)
January 8, 2020 Wendy Nelson
240-276-6971
nelsonw@mail.nih.gov
Optional
Tobacco Use and HIV in Low and Middle Income Countries PAR-18-023 (R01 Clinical Trial Optional)
PAR-18-022 (R21 Clinical Trial Optional)
January 8, 2020 Mark Parascandola
240-276-6871
Mark.Parascandola@nih.gov
Optional
Fundamental Mechanisms of Affective and Decisional Processes in Cancer Control PAR-18-681 (R01 Clinical Trial Optional) October 12, 2019 Rebecca Ferrer
301-852-1167
rebecca.ferrer@nih.gov
Optional
Target Assessment, Engagement and Data Replicability to Improve Substance Use Disorders Treatment Outcomes PAR-18-086 (R21/R33 Clinical Trial Optional)
PAR-18-085 (R33 Clinical Trial Optional)
September 8, 2019 Glen Morgan
240-276-6787
gmorgan@nih.gov
Optional
Integrative Research on Polysubstance Abuse and Addiction PAR-18-084 (R21/R33 Clinical Trial Optional) September 8, 2019 Glen Morgan
240-276-6787
gmorgan@nih.gov
Optional
Improving Smoking Cessation in Socioeconomically Disadvantaged Populations via Scalable Interventions PAR-18-251 (R01 Clinical Trial Optional)
PAR-18-250 (R21 Clinical Trial Optional)
June 14, 2019 Yvonne Prutzman
240-276-6975
huntym@mail.nih.gov
Optional
Accelerating the Pace of Drug Abuse Research Using Existing Data PAR-18-062 (R01 Clinical Trial Optional) May 8, 2019 Annette Kaufman
240-276-6706
kaufmana@mail.nih.gov
Optional
Predicting Behavioral Responses to Population-Level Cancer Control Strategies PAR-18-024 (R21 Clinical Trial Optional) April 12, 2019 Rebecca Ferrer
240-276-5075
ferrerra@mail.nih.gov
Optional
Tobacco Regulatory Science RFA-OD-18-002 (R01 Clinical Trial Optional)
RFA-OD-18-003 (R21 Clinical Trial Optional)
February 14, 2019 Rachel Grana Mayne
240-276-5899
rachel.mayne@nih.gov
Optional
Tobacco Regulatory Science Small Grant Program for New Investigators RFA-OD-18-001 (R03 Clinical Trial Optional) February 14, 2019 Rachel Grana Mayne
240-276-5899
rachel.mayne@nih.gov
Optional
Communication and Decision Making for Individuals with Inherited Cancer Syndromes RFA-CA-19-001 (U01 Clinical Trial Optional) January 10, 2019 Wendy Nelson
240-276-6971
nelsonw@mail.nih.gov
Optional
Improving Smoking Cessation Interventions among People Living with HIV RFA-CA-18-027 (R01 Clinical Trial Optional)
RFA-CA-18-028 (R21 Clinical Trial Optional)
January 9, 2019 Annette Kaufman
240-276-6706
kaufmana@mail.nih.gov
Optional
Revision Applications for Validation of Mobile/Wireless Health Tools for Measurement and Intervention PA-18-339 (R01 Clinical Trial Optional) January 8, 2019 April Oh
240-276-6709
april.oh@nih.gov
Optional
Education and Health: New Frontiers PAR-18-387 (R01 Clinical Trial Optional)
PAR-18-388 (R03 Clinical Trial Optional)
PAR-18-362 (R21 Clinical Trial Optional)
January 8, 2019 Todd Horowitz
240-276-6963
horowitzts@mail.nih.gov
Optional
Mechanism for Time-Sensitive Drug Abuse Research PAR-18-064 (R21 Clinical Trial Optional) November 9, 2018 Kelly Blake
240-281-5934
kelly.blake@nih.gov
Optional
Interdisciplinary Research Teams to Investigate Reciprocal Basic Behavioral and Social Linkages Between Sleep and Stress PAR-18-694 (R24 Clinical Trial Optional) November 30, 2018 Kara Hall
240-276-6831 hallka@mail.nih.gov

Todd Horowitz
240-678-5986
todd.horowitz@nih.gov
Optional

Cancer Survivorship

Title Announcement Expiration Date Contact Clinical Trial Optional / Required?
Examination of Survivorship Care Planning Efficacy and Impact PA-18-002 (R01 Clinical Trial Optional) 
PA-18-012 (R21 Clinical Trial Optional) 
July 8, 2019 Janet de Moor
240-276-6806
demoorjs@mail.nih.gov
Optional

Epidemiology and Genomics Research

Title Announcement Expiration Date Contact Clinical Trial Optional / Required?
Age-related Microbiota Changes and their Implications in Chronic Disease Prevention, Treatment and Progression Announcement Numbers PA-18-738 (R01 Clinical Trial Optional)
PA-18-739 (R21 Clinical Trial Optional)
May 8, 2021 Tram Lam
240-276-6967
lamt@mail.nih.gov
Optional
Advancing Translational and Clinical Probiotic/Prebiotic and Human Microbiome Research PA-18-001 (R01 Clinical Trial Optional) May 8, 2021 Andrew N. Freedman
240-276-6697
Andrew_Freedman@nih.gov
Optional
Modular R01s in Cancer Control and Population Sciences PAR-18-869 (R01 Clinical Trial Optional) March 9, 2021 Scott Rogers
240-276-6932
rogerssc@mail.nih.gov
Optional
Improving Outcomes in Cancer Treatment-Related Cardiotoxicity PA-18-003 (R01 Clinical Trial Optional) 
PA-18-013 (R21 Clinical Trial Optional)
July 8, 2019 Nonniekaye Shelburne
240-276-6897
nshelburne@mail.nih.gov
Optional
Approaches to Identify and Care for Individuals with Inherited Cancer Syndromes RFA-CA-19-017 (U01 Clinical Trial Required) January 10, 2019 Nonniekaye Shelburne
240-276-6897
nshelburne@mail.nih.gov

Erica Breslau
240-276-6773
breslaue@mail.nih.gov
Required

Healthcare Delivery Research

Title Announcement Expiration Date Contact Clinical Trial Optional / Required?
Increasing Uptake of Evidence-Based Screening in Diverse Adult Populations PA-18-932 (R01 Clinical Trial Optional) January 08, 2022 Erica Breslau
240-276-6773
breslaue@mail.nih.gov
Optional
Using Information Technology to Support Systematic Screening and Treatment of Depression in Cancer PA-18-492 (R21 Clinical Trial Optional)
PA-18-493 (R01 Clinical Trial Optional)
May 8, 2021 Gurvaneet Randhawa
240-276-6940
gurvaneet.randhawa@nih.gov
Optional
Multilevel Interventions in Cancer Care Delivery: Follow-up to Abnormal Screening Tests PAR-17-495 (R01 Clinical Trial Optional) January 8, 2021 Erica Breslau
240-276-6773
breslaue@mail.nih.gov
Optional
Reducing Overscreening for Breast, Cervical, and Colorectal Cancers among Older Adults PA-18-005 (R01 Clinical Trial Optional)
PA-18-015 (R21 Clinical Trial Optional)
January 8, 2020 Erica Breslau
240-276-6773
breslaue@mail.nih.gov
Optional
Linking the Provider Recommendation to Adolescent HPV Vaccine Uptake PAR-18-019 (R21 Clinical Trial Optional)
PAR-18-008 (R01 Clinical Trial Optional)
July 17, 2019 Sarah Kobrin
240-276-6931
kobrins@mail.nih.gov
Optional
Intervening with Cancer Caregivers to Improve Patient Health Outcomes and Optimize Health Care Utilization PAR-18-246 (R01 Clinical Trial Optional)
PAR-18-247 (R21 Clinical Trial Optional)
April 12, 2019 Michelle Mollica
240-276-7621
mollicama@mail.nih.gov
Optional
Implementation Science for Cancer Control: Advanced Centers RFA-CA-19-005 (P50 Clinical Trial Optional)
RFA-CA-19-006 (P50 Clinical Trial Optional)
February 12, 2019 April Oh
240-276-670
ohay@mail.nih.gov

Cynthia Vinson
240-276-6745
cvinson@mail.nih.gov
Optional
Accelerating Colorectal Cancer Screening and follow-up through Implementation Science (ACCSIS, Second Wave) RFA-CA-19-018 (UG3/UH3 Clinical Trial Required) February 12, 2019 Sarah Kobrin
240-276-6931
sarah.kobrin@nih.gov
Required

Health Disparities Research

Title Announcement Expiration Date Contact Clinical Trial Optional / Required?
Intervention Research to Improve Native American Health PAR-17-496 (R01 Clinical Trial Optional) May 15, 2020 Shobha Srinivasan
240-276-6936
ss688k@nih.gov
Optional
Research to Improve Native American Health PAR-17-464 (R21 Clinical Trials Optional) May 15, 2020 Shobha Srinivasan
240-276-6936
ss688k@nih.gov
Optional
Administrative Supplements to Support Cancer Disparity Collaborative Research PA-18-842 (Clinical Trial Optional) September 11, 2018 Damali Martin
240-276-6746
martinda@mail.nih.gov
Optional

Implementation Science

Title Announcement Expiration Date Contact Clinical Trial Optional / Required?
Dissemination and Implementation Research in Health PAR-18-007 (R01 Clinical Trial Optional) 
PAR-18-017 (R21 Clinical Trial Optional) 
May 8, 2020 Gila Neta
240-276-6785
netagil@mail.nih.gov
Optional