Intervention Research to Improve Native American Health (IRINAH)

Intervention Research to Improve Native American Health (IRINAH), a network of principal investigators and their partners, funded by the National Institutes of Health (NIH), was launched in 2011 through a program titled “Interventions for Health Promotion and Disease Prevention in Native American (NA) Populations.”

Native American populations are exposed to considerable risk factors that significantly increase their likelihood of chronic disease, substance abuse, mental illness, oral disease, and HIV infection. The IRINAH program was created to develop, adapt, and test the effectiveness of health-promotion and disease-prevention interventions in NA populations. The long-term goal of the notice of funding opportunity (NOFO) is to reduce mortality and morbidity in NA communities. IRINAH also provides a forum for discussions on the challenges and opportunities to improve health in NA populations across the United States.

The first funding opportunity was through PAR-11-346, followed by the second round of funding in 2014 (PAR-14-260), and a reissuance in 2017 for both R01 (PAR-17-464) and R21 (PAR-17-496) applications and again in 2020 for both R01 (PAR-20-238) and R21 (PAR-20-214). The most recent reissuance was in 2023 for both R01 (PAR-23-298) and R21 (PAR-23-299), which also included a funding opportunity for R34 (PAR-23-285) applications, with the following due dates: October 21, 2024; October 21, 2025; and October 21, 2026.

A webinar on the IRINAH Program was held on January 25, 2024  to discuss the new NOFOs—R01 PAR-23-298, R21 PAR-23-299, and R34 PAR-23-285.  The webinar materials are available below:


Contact Dr. Alexa Romberg at or Dr. Sarah Vidal at  

Webinar Flyer

Participating Organizations

  • National Institute on Drug Abuse (NIDA)

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

  • National Institute of Allergy and Infectious Diseases (NIAID)

  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

  • National Institute of Biomedical Imaging and Bioengineering (NIBIB)

  • National Institute of Dental and Craniofacial Research (NIDCR)

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  • National Institute of Environmental Health Sciences (NIEHS)

  • National Institute of Mental Health (NIMH)

  • National Institute of Nursing Research (NINR)

  • National Institute on Minority Health and Health Disparities (NIMHD)

  • National Library of Medicine (NLM)

  • National Cancer Institute (NCI)

  • National Center for Complementary and Integrative Health (NCCIH)

  • National Institute of Child Health and Human Development (NICHD)

  • National Heart, Lung, and Blood Institute (NHLBI)

  • National Institute on Deafness and Other Communication Disorders (NIDCD)

All applications to this notice of funding opportunity should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

  • Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)

  • Office of Behavioral and Social Sciences Research (OBSSR)

  • Office of Research on Women's Health (ORWH )

Last Updated
February 29, 2024