
The Implementation Science Centers in Cancer Control (ISC3) Program supports the development, testing, and refinement of innovative approaches to implement evidence-based cancer control interventions.
All Centers feature "implementation laboratories" involving clinical and community sites. These sites will engage in implementation research across the cancer control continuum to:
- advance methods in studying implementation
- develop and validate reliable measures of key implementation science constructs
These Centers provide leadership for an Implementation Science consortium across this and other Cancer MoonshotSM initiatives.
Implementation Science Centers (P50s)
The ISC3 Program is composed of seven Centers funded by RFA-CA-19-005 and RFA-CA-19-006.

Center | PI/MPI | Institution | Grant # |
---|---|---|---|
The Implementation Science Center for Cancer Control Equity (ISCCCE) |
Karen Emmons |
Harvard T.H. Chan School of Public Health | |
Building Research in Implementation and Dissemination to close Gaps and achieve Equity in Cancer Control Center (BRIDGE-C2) | Jennifer DeVoe Heather Angier Nathalie Huguet |
Oregon Health & Science University | |
Colorado Implementation Science Center in Cancer Control (Colorado ISC3) |
Russell E. Glasgow |
University of Colorado School of Medicine | |
Optimizing Implementation in Cancer Control (OPTICC) |
Bryan J. Weiner |
University of Washington | |
Implementation and Informatics – Developing Adaptable Processes and Technologies for Cancer Control (iDAPT) |
Kristie Long Foley |
Wake Forest School of Medicine/University of Massachusetts Medical School | |
Washington University Implementation Science Center for Cancer Control (WU-ISCCC) |
Ross C. Brownson |
Washington University in St. Louis | |
Penn Implementation Science Center in Cancer Control (Penn ISC3) |
Rinad Beidas |
University of Pennsylvania/Northwestern University |
Overview of Implementation Science Themes
Research activities for the Centers are organized around a cohesive, overarching implementation science theme that frames their activities and research agenda.
- Harvard T.H. Chan School of Public Health: The Implementation Science Center for Cancer Control Equity at Harvard is improving community health by integrating health equity and implementation science for evidence-based cancer control.
- Oregon Health & Science University: The BRIDGE-C2 Center will focus on advancing implementation science to improve cancer screening and prevention in underserved populations.
- University of Colorado School of Medicine: University of Colorado Denver will focus on pragmatic approaches to assess and enhance the value of cancer prevention and control in rural primary care.
- University of Pennsylvania: The Penn ISC3 will apply insights from behavioral economics to rapidly accelerate the pace at which evidence-based practices for cancer care are deployed and to which they are delivered equitably, thereby increasing their reach and impact on the health of individuals with cancer.
- University of Washington: The OPTICC Center will develop, test, and refine innovative methods for optimizing the implementation of evidence-based interventions in cancer control.
- Wake Forest School of Medicine: iDAPT will advance the field of implementation science by using technologies to support rapid cycle and real-time deployment and testing of implementation processes and adaptations within cancer control.
- Washington University in St. Louis: The WU-ISCCC will build a rigorous, scientific evidence base for rapid-cycle implementation research to increase the reach, external validity, and sustainability of effective cancer control interventions. The Center’s goal and activities capture three distinct features: (1) a focus on elimination of cancer disparities; (2) the need for rapid-cycle studies; and (3) the use of systems science approaches to enhance methods and outcomes in implementation science.
NCI ISC3 Staff






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