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National Cancer Institute

Adherence to Oral Anticancer Agents

Funding Opportunity

Oral Anticancer Agents: Utilization, Adherence, and Health Care Delivery (ROA & R21)

This Funding Opportunity Announcement (FOA) encourages research grant applications to (1) assess and describe the current state of oral anticancer medication utilization, delivery, and adherence; (2) identify structural, systemic, and psychosocial barriers to adherence; and (3) develop models and strategies to improve safe and effective delivery of these agents so that clinical outcomes are optimized. For more details, please review the full program announcements: PA-17-060 (R01) and PA-17-061 (R21). For inquiries about this funding announcement, please contact: Wendy Nelson.

Standard application due dates apply.  Earliest submission date is January 5, 2017.

Text: Watch the webinar on this funding announcement.

Summary

The clinical use of oral anticancer (OAC) agents, particularly molecularly targeted agents, has grown dramatically in recent years, and it is expected that the rate of development, approval, and use of these medications will continue to increase. Maximal benefit from OAC agents can only be achieved if used properly, which is often difficult due to complex treatment regimens and dosing schedules. Suboptimal adherence can result in poor survival, side-effects and toxicities, unnecessary treatment change, and increased use of health resources. While home-based treatment offers many advantages, at the same time it requires that patients and caregivers assume primary responsibility for symptom management. Whereas traditional parenteral chemotherapy is administered in controlled clinical settings, the newer OAC medications are administered and monitored by patients and caregivers in the home.

BBPSB encourages research that will help to understand the individual-level factors that influence adherence: cognitive factors, affective factors, biological factors, and motivational factors. Adherence to OAC therapy should be viewed holistically and considered in the context of the patient’s clinical status, comorbid conditions, treatment expectations, and social situation. In addition to understanding the role of individual patient-level factors, it is also important to understand the role of clinicians (e.g., physicians, nurses), pharmacists, and caregivers in shaping adherence behavior.

Contact

Adherence-related questions:
Wendy Nelson, Ph.D.
Program Director
nelsonw@mail.nih.gov

Utilization-related questions:
Kelly K. Filipski, Ph.D., M.P.H.
Program Director
filipskikk@mail.nih.gov

Health Care Delivery-related questions:
Kathleen Castro, RN, MS, AOCN®
Program Director
castrok@mail.nih.gov