The purpose of the working group is to promote the exchange of information and interests in obesity and cancer research interests within NCI. Our activities include the development of meetings, workshops and webinars, scientific manuscripts, conduct portfolio review, and identify funding opportunities in obesity and cancer research. Five subgroups have been formed: Prevention, Etiology, and Mechanisms, Treatment and Survivorship , Measurement and Methods, Health Disparities, and Time-Restricted Eating.
- Identify and summarize the state-of-the-science to document what is known and what is needed to move the science forward
- Identify and prioritize critical research questions/needs/gaps in each topic area
- Develop research concept themes and other activities to stimulate research
- Plan and develop a webinar series with topics related to the different subgroups
The Prevention, Etiology, and Mechanisms subgroup is exploring the following:
- What are the risk factors, biological mechanisms and pathways associated with excess body weight and/or adiposity driving the development of pre- and invasive cancers across the lifespan in all racial/ethnic and understudied populations across geographic locations?
- Does overweight/obesity in children and youth increase the risks for cancer development later in life?
- How do risk factors, such as sleep, stress, social determinants of health, the microbiome, metabolic and immune dysfunction, environmental obesogens, influence and/or interact with mechanisms through which obesity might increase risk of cancer?
- What effective strategies could prevent or intercept mechanistic biological changes such as inflammation, immune function, and metabolic dysregulation of obesity associated cancers?
- Does the timing, duration, and amount of weight loss in the life cycle influence cancer risk (i.e. in childhood/youth versus adult)?
- Which interventions decrease obesity and associated unhealthy lifestyle behaviors, applied across the lifespan, to reduce and/or delay cancer incidence?
The Treatment and Survivorship subgroup is exploring the following:
What are the effects of diet, exercise and body composition on cancer treatment efficacy & outcomes?*
- Better characterization of optimal type, dose, frequency, duration, timing of exercise & diet on chemotherapy uptake, adherence, side effects, treatment response & clinical outcomes
- Greater understanding of the relationships between obesity/body composition, cancer progression, and response to treatment
What are the effects of obesity/body composition, exercise & dietary regimens on post-treatment outcomes?*
- Better characterization of post-treatment exercise and diet interventions on long-term treatment related toxicities and clinical outcomes, QoL, sleep, and general health outcomes.
- Better precision weight maintenance/loss interventions for cancer survivors
*These questions need to be addressed across cancer sites/subtypes and in diverse groups of survivors with respect to age, body size, activity level, and race/ethnicity.
Measurement and Methods
The Measurement and Methods subgroup is exploring the following:
- How can complementary assessment methods (e.g., self-report, sensor-based technologies, and/or biomarkers) be triangulated to improve insights into diet, physical activity, and sleep behaviors and environmental determinants?
- What assessment and analytic methods are needed to better integrate measures of the 24-hour patterns of diet, physical activity, and sleep?
- How can dietary assessment tools be developed or adapted to capture the context of eating (when, where, why, with whom) for cancer survivors?
- How can methods be enhanced to measure the food and physical activity environment in diverse populations using appropriate reference instruments?
The Health Disparities subgroup is exploring the following:
Why do cancer and the health consequences of obesity disproportionately affect Hispanics, non-Hispanic Blacks, and Native Americans more than other race and ethnic groups?
- Geography, economy, health care access, internet access, culturally-sensitive communication, differences in lifestyle, and citizenship status all contribute to the impact of the ability of diverse patient populations to seek and receive cancer information and care related to cancer prevention, screening and treatment - including risks/benefits associated with various treatment modalities - in equitable fashion.
- Need for greater understanding of the intersection of cancer, obesity and disparities within racially-ethnically diverse populations in the basic/translational, clinical and population sciences.
- Enhance understanding of the underlying factors associated with rising obesity rates, especially among vulnerable populations.
How can we tailor interventions influencing weight loss, exercise & dietary regimens to have better outcomes in diverse populations to reduce cancer risk?
- Better characterization of optimal delivery of interventions, type, dose, frequency, duration, timing of exercise & diet on health behavior outcomes & QoL
- Identify evidence-based interventions and strategies to improve weight, physical exercise, and diet, including effective ways to ensure affordability and address barriers, such as those relating to SES and environmental constraints (e.g. time constraints) that pose obstacles to implementing such strategies.
The Time-Restricted Eating subgroup is exploring the following:
- What are the effects of time-restricted eating (TRE) compared to other diet strategies, including, but not limited to, intermittent and/or daily fasting, on weight loss, weight maintenance, and long-term dietary adherence?
- What role does TRE play in reducing cancer incidence and progression, cancer treatment response, and cancer recurrence?
- What are the emerging obesity risk factors, including the hormonal milieu, microbiome, and epigenetic modifications that impact TRE’s efficacy?
|Title||Announcement #||Expiration Date||Contact(s)|
|Research Answers to National Cancer Institute's (NCI) Provocative Questions PQ’s 1 and 2||RFA-CA-20-004 (R01 Clinical Trial Optional) RFA-CA-20-005 (R21 Clinical Trial Optional)||
November 18, 2020
|Sean Hanlon 240-781-3310 email@example.com|
|Physical Activity and Weight Control Interventions Among Cancer Survivors: Effects on Biomarkers of Prognosis and Survival||PAR-18-893 (R01 Clinical Trial Optional) PAR-18-892 (R21 Clinical Trial Optional)||
September 8, 2021
|Frank M. Perna 240-276-6782 firstname.lastname@example.org Sharon A. Ross 240-276-7124 email@example.com|
|Stimulating Innovations in Behavioral Intervention Research for Cancer Prevention and Control||PAR-19-309 (R21 Clinical Trial Optional)||
September 08, 2022
|Tanya Agurs-Collins, 240-276-6956 firstname.lastname@example.org|
|Research to Reduce Morbidity and Improve Care for Pediatric, and Adolescent and Young Adult (AYA) Cancer Survivors||RFA-CA-20-027 (R01 Clinical Trial Optional) RFA-CA-20-028 (R21 Clinical Trial Optional)||
July 31, 2021
|Michelle Mollica 240-276-7621 email@example.com Danielle Daee 240-276-5744 firstname.lastname@example.org|
|Improving Outcomes in Cancer Treatment-Related Cardiotoxicity||PA-19-112 (R01 Clinical Trial Optional) PA-19-111 (R21 Clinical Trial Optional)||
January 8, 2022
|Nonniekaye Shelburne 240-276-6897 email@example.com|
|Diet and Physical Activity Assessment Methodology||PA-18-856 (R01 Clinical Trial Not Allowed) PAR-18-857 (R21 Clinical Trial Not Allowed)||
September 08, 2021
|Richard Troiano 240-276-6916 firstname.lastname@example.org (For applications that focus on physical activity) Nancy J. Emenaker 240-276-7125 email@example.com (For applications that focus on dietary biomarkers, including new objective recovery markers, and predictive biomarkers for dietary constituents and foods) Kirsten Herrick 240-276-7920 firstname.lastname@example.org (For applications that focus on dietary assessment or dietary methods)|
Obesity & Cancer Webinar Series
The Obesity and Cancer Webinar Series will include a wide range of obesity and cancer topics in basic to behavioral, and lab, clinical to community-focused research format.
- The Interface of Insulin Resistance, Chronic Inflammation and Cancer Risk June 3, 2021
- Obesity, the Microbiome and Cancer September 2, 2021
- Countering the Impact of COVID-19-related Economic and Social Disruption on Childhood Obesity December 2, 2021
- Look AHEAD Research Group, Yeh HC, Bantle JP, Cassidy-Begay M, et al. Intensive weight loss intervention and cancer risk in adults with type 2 diabetes: analysis of the Look AHEAD randomized clinical trial. Obesity (Silver Spring). 2020;28(9):1678-1686. doi: 10.1002/oby.22936.
- Agurs-Collins T, Ross SA, Dunn BK. The Many Faces of Obesity and Its Influence on Breast Cancer Risk. Front Oncol. 2019 Sep 4;9:765. doi: 10.3389/fonc.2019.00765.
- Schauer DP, Feigelson HS, Koebnick C, et al. Bariatric surgery and the risk of cancer in a large multisite cohort. Ann Surg. 2019;269(1):95-101. doi: 10.1097/SLA.0000000000002525.
- Campbell KL, Winters-Stone KM, Wiskemann J, et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Medicine & Science in Sports & Exercise. 2019;51(11):2375-2390. doi: 10.1249/MSS.0000000000002116.
- de Cabo R, Mattson MP. Effects of intermittent fasting on health, aging, and disease. New England Journal of Medicine, 2019;381(26):2541-2551. doi: 10.1056/NEJMra1905136.
- Matthews CE, Keadle SK, Berrigan D, et al. Influence of accelerometer calibration approach on MVPA estimates for adults. Med Sci Sports Exerc. 2018;50(11):2285-2291. doi: 10.1249/MSS.0000000000001691.
- Park Y, Dodd KW, Kipnis V, et al. Comparison of self-reported dietary intakes from the Automated Self-Administered 24-h recall, 4-d food records, and food-frequency questionnaires against recovery biomarkers. The American Journal of Clinical Nutrition. 2018;107(1), 80-93. doi: 10.1093/ajcn/nqx002.
- Arends J, Bachmann P, Baracos V, et al. ESPEN guidelines on nutrition in cancer patients. Clinical Nutrition. 2017;36(1):11-48. doi: 10.1016/j.clnu.2016.07.015.
- Energy balance and obesity. IARC Working Group Reports, Volume 10, Edited by Isabelle Romieu, Laure Dossus, and Walter C. Willett. Chapter 12. Molecular and metabolic mechanisms underlying the obesity–cancer link, Ciara H. O’Flanagan, Laura W. Bowers, Emma H. Allott, and Stephen D. Hursting. 2017, International Agency for Research on Cancer, Lyon, France.
- Patterson RE, Sears DD. Metabolic effects of intermittent fasting. Annu Rev Nutr. 2017;21;37:371-393. doi: 10.1146/annurev-nutr-071816-064634.
- Rock CL, Doyle C, Demark-Wahnefried W, et al. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin. 2012;62(4):243-74. doi: 10.3322/caac.21142