Monograph 20 Phenotypes and Endophenotypes: Foundations for Genetic Studies of Nicotine Use and Dependence

Monograph 20 Cover

Reviews literature on genetic studies of nicotine use and dependence and presents a scientific plan for incorporating genetic research into cross-disciplinary studies of nicotine dependence. Chapters highlight theoretical considerations (including linking heritable genetic traits with nicotine dependence), modeling developmental trajectories to dependence, candidate endophenotypes, epidemiological and methodological considerations, and future directions.

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The tobacco monographs can be ordered by sending an email to Please include the title and/or NCI Publication Number and the requested quantity.*

* Both Executive Summary (Publication ID: T141) and full reports (Publication ID: T140) available.

Suggested Citation

National Cancer Institute. Phenotypes and Endophenotypes: Foundations for Genetic Studies of Nicotine Use and Dependence. Tobacco Control Monograph No. 20. Bethesda, MD: U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute. NIH Publication No. 09-6366, August 2009.

View Individual Chapters

Chapters and key topics covered within each chapter are listed below. Chapters generally include an introductory section, details on methodology, a chapter summary, research needs, and a reference list.

Part 1. Introduction (PDF, 43 KB)

Part 2. Theoretical Considerations (PDF, 43 KB)

Part 3. Developmental Trajectories of Tobacco Use and Their Relation to Tobacco Dependence (PDF, 44 KB)

Part 4. Endophenotypes (PDF, 42 KB)

Part 5. Epidemiological and Methodological Considerations (PDF, 46 KB)

Part 6. Future Directions (PDF, 49 KB)

Last Updated
September 24, 2020