Insulin, Glucagon, HOMA-IR, HOME-6, HBA1c

Measure Definition:

Fasting levels of insulin, glucagon, and glycosylated hemoglobin (HbA1C) can be measured before, during, and after weight loss. Along with the metabolite data, these measures can be utilized to calculate indices of insulin sensitivity and secretion (homeostatic model assessment of insulin resistance and homeostatic model assessment for b-cell function (88). 


Laboratory Procedure

Construct Definition (and Source):

Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting. (NCI)

Selected References

Citation PubMed ID

Courcoulas A, Christian M, O’Rourke R, et al. Preoperative factors and 3-year weight change in the Longitudinal Assessment of Bariatric Surgery (LABS) consortium. Surg Obes Relat Dis 2015;11:1109-1118.

Look AHEAD Study Group; Espeland M, Bray G, Neiberg R, et al. Describing patterns of weight changes using principal components analysis: results from the Action for Health in Diabetes (Look AHEAD) research group. Ann Epidemiol 2009; 19:701-710.

Cornier M, Donahoo W, Pereira R, et al. Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women. Obes Res 2005;13:703-709.