Tobacco Regulatory Science

With the passage of the Family Smoking Prevention and Tobacco Control Act (often called the Tobacco Control Act) in 2009, the Food and Drug Administration (FDA) acquired the authority to regulate the manufacture, marketing, and distribution of tobacco products in order to protect public health and established within FDA a new Center for Tobacco Products (FDA CTP). Within the framework of the Tobacco Control Act, the NIH and FDA CTP formed an interagency partnership to foster tobacco regulatory research. The NIH has the infrastructure for the solicitation, review, and management of research, and several NIH Institutes and Centers have long supported tobacco-related research as part of their missions. The FDA has expertise in tobacco regulatory science and the authority and resources to support research responsive to FDA CTP’s tobacco regulatory authority. NIH biomedical, behavioral and social sciences research supported via funding from FDA will provide the scientific evidence needed to better inform FDA’s regulatory authorities.

In collaboration with the NIH Tobacco Regulatory Science Program (TRSP), the National Cancer Institute is developing an evidence base to inform the FDA CTP regulatory authority over the manufacture, marketing, and distribution of tobacco products in order to protect public health. Although a vast and sound scientific evidence base exists to support the Tobacco Control Act, new research will provide scientific evidence in several areas.

Funded Grants under Tobacco Regulatory Science Program

Click the link below to view a list of NIH grants (including NCI) funded through the Tobacco Regulatory Science Program in current and prior fiscal years. These grants are funded by the FDA Center for Tobacco Products through various NIH Funding Opportunity Announcements. View the entire research portfolio here. View a list of archived announcements here.

NIH-FDA Tobacco Regulatory Science Program (TRSP) Funded Grants

Funding Opportunities

View all Tobacco Regulatory Science Funding Opportunities.


Overview of the Family Smoking Prevention and Tobacco Control Act

Tobacco Regulatory Science Publications

Themed Issue on Eye Tracking exit disclaimer (Tobacco Regulatory Science, November 2018)
Themed Section about the Tobacco Control Act exit disclaimer (Nicotine & Tobacco Research, January 2012)
Progress Reports (FDA Center for Tobacco Products)
The Role of Mentholated Cigarettes in Smoking Behaviors in United States Populations exit disclaimer (Addiction Special Issue, December 2010)


Cancer Trends Progress Report (National Cancer Institute)
Reports of the Surgeon General, U.S. Public Health Service (Dept. Health and Human Services)
Smoking Tobacco Use: Data and Statistics (Centers for Disease Control and Prevention)
Tobacco Control Monograph Series (National Cancer Institute)
Tobacco Use Supplement to the Current Population Survey (National Cancer Institute)


Rachel Grana Mayne Rachel Grana Mayne, Ph.D.
Program Director