Decoding the Cellular Aging Landscape: Insights into Cancer Susceptibility and Treatment Tolerance

Aging is a risk factor for cancer, and evidence suggests that cancer and its treatments can accelerate aging. Aging is associated with a myriad of cellular and molecular alterations, including epigenetic changes. In this webinar, Dr. Mark LaBarge will discuss his work investigating how aging-related epigenetic changes in the luminal cells of the mammary gland can lead to increased susceptibility to breast cancer, and why this knowledge offers opportunities for breast cancer prevention and early detection. Dr. Alexandra Binder will describe the use of epigenetic clocks, a surrogate for biological age, to predict chemotherapy tolerance among colon cancer patients and the promise of a resistance training intervention to maintain or build muscle mass in reducing the rate of epigenetic aging during chemotherapy.

This webinar is part of the Perspectives on Cancer and Aging: The Arti Hurria Memorial Webinar Series. It is co-hosted by the NCI Behavioral Research Program and Epidemiology and Genomics Research Program.

Reasonable Accommodations

Closed captioning will be available to all participants. Individuals who need reasonable accommodations to participate in this event should contact ncidccpsbrpadvances@mail.nih.gov. Requests should be made at least five business days in advance of the event.